From Milan: autostrada A1 direction Bologna/Firenze - take the exit Florence-Scandicci, and follow the superstrada (S.G.C.) Florence-Pisa-Livorno (FI.PI.LI.).
Take the exit Empoli West and follow the sign Fucecchio-Cerreto Guidi.
Take the underground and drive untile the crossing.
Keep going straight on over the bridge.
By the turn-about take the second exit (direction Fucecchio). After 50 meters on the left there is Borgo Filicaja.
From Roma:
Autostrada A1 direction Florence follow the same directions as above.